Stimuli Responsive In Situ Gelling Systems Loaded with PLGA Nanoparticles of Moxifloxacin Hydrochloride for Effective Treatment of Periodontitis

Formulation and evaluation of Moxifloxacin hydrochloride ocular nanoparticles

The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated i...

in situ gelling systems for drug delivery

Formulation and evaluation of Moxifloxacin hydrochloride ocular nanoparticles

The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated i...

Development and Evaluation of In Situ Gelling System for Treatment of Periodontitis

Periodontitis is an inflammatory disease of the supporting tissues of the teeth caused by groups of specific microorganisms. The concept that localized problem sites may be treated by local drug delivery appears attractive as the antimicrobial agent is delivered within periodontal pockets and the therapy is targeted on specific pathogenic microorganisms. Local delivery of antimicrobial agents u...

Moxifloxacin in situ gelling microparticles–bioadhesive delivery system

Antibiotic use for ocular treatments has been largely limited by poor local bioavailability with conventional eyedrops formulations. Here, we developed a controlled delivery system composed of moxifloxacin-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulated in a chondroitin sulfate-based, two-component bioadhesive hydrogel. Using a simple and fast electrohydrodynamic spray d...